Decoding the Lysosome

from fundamental biology to disease

Lysosomes are central to a network of signaling and metabolic processes and their dysfunction contributes to diverse diseases, from cancer to neurodegeneration. Yet, fundamental aspects of lysosomal function remain unclear, limiting their therapeutic potential. For example, how do lysosomes degrade complex cargos? How does the rest of the cell interface with products of lysosomal catabolism? And can cells sense and respond to perturbations in lysosomal catabolism?

To address these questions, our lab integrates organelle reconstitution, bioinformatics, multi-omics, biochemical and cell biological approaches to achieve a systems-level understanding of lysosomal catabolism, paving the way for new therapeutic strategies against cancer and degenerative diseases.